Analysis of BALF specimens 21 days after treatment.

<p>(A) Both silica treated WT and RAGE KO (closed bars) had significantly more total cells per mL in the BALF compared to control treated mice (open bars). There was not a significant difference between WT and RAGE KO mice. Furthermore, the number of macrophages in both WT and RAGE KO BALF was not significantly increased over control treated mice (B). While the level of neutrophils increased significantly with silica treatment compared to controls for both strains (C), only RAGE KO mice had a significant increase in lymphocytes after silica treatment (D). (E) Protein concentration in the BALF also increased significantly with treatment, but there was no difference between the two strains. Data are means (±SEM) analyzed by 2-way ANOVA with a Bonferroni post-test. (<i>n = 6–7 per group</i>). * p<0.05 silica vs. control.