Intratracheal zymosan caused increased lung inflammation and NF-κB activation, in gp91<i>^phox-</i>deficient (X-linked CGD) versus wildtype mice.

<p>A) Representative lung section of gp91<i>^phox-</i>deficient mouse 6 days after i.t. zymosan showing extensive inflammation (H&E, 100x). Similarly treated wildtype (WT) mice had no lung inflammation (not shown). B) On day 6 after i.t. zymosan, both NADPH oxidase deficient genotypes (p47<i>^phox−/−</i> and gp91<i>^phox−/</i>) had similar BALF neutrophilic leukocytosis, whereas monocytes predominated in WT BALF. C) gp91<i>^phox-</i>deficient/HLL mice had increased whole lung NF-κB activation compared to WT/HLL mice.