Vaccine Protection against lethal-dose challenge of H5N1 virus.

<p>At day 42, vaccinated mice were challenged intranasally with a lethal dose (100 LD₅₀) of recombinant H5N1 (NIBRG-14) virus and monitored daily for weight loss and mortality. The percentages of survival rate and changes of body weight and temperature were recorded. (A) Survival for H5N1-VLP groups, (B) survival for IWV groups, Mice that lost greater than 30% body weight were euthanized. (C) Body weight and temperature for H5N1-VLP groups. For th groups receiving 0.3 µg and 1.5 µg antigen dose, only data of surviving mice are shown. (D) Body weight and temperature for IWV groups.