Dose response to silica.

<p>(A) The high dose of silica resulted in a significantly higher increase in total cells/mL in the BALF of RAGE KO mice compared to WT mice. (B) RAGE KO mice had more macrophages than WT at the high dose of silica. (C) Neutrophil levels were significantly lower in RAGE KO mice compared to WT mice for all doses of silica. (D) Lymphocyte levels were different among the two strains at the two lower doses of silica. (E) RAGE KO mice had a significant higher level of protein in the BALF after all doses of silica compared to WT mice. (F) Hydroxyproline assay showed no difference in collagen deposition between the two strains. Low; 0.2 mg, medium; 1 mg, high; 5 mg silica. Data are means (±SEM) analyzed by 2-way ANOVA with a Bonferroni post-test. (<i>n = 6–7 per group</i>). * p<0.05 silica vs. control, ** p<0.05 WT vs. RAGE KO.