Effects of PPAR agonists on vascular tissue.

<p>The vaso-relaxant responses of three different PPAR agonists in (A) pulmonary artery, (B) aorta and (C) mesenteric artery. GW501516 or GW0742, which activate PPARβ/δ, rosiglitazone, which activates PPARγ or bezafibrate, which activates PPARα, were added to U46619 [EC₈₀] contracted arteries in increasing concentrations. Responses of vehicle (DMSO; final accumulated maximum of 0.6%) are shown as ‘vehicle control’. The data is the mean ± standard error of the mean for n = 4−8 experiments. Drug induced responses were compared with time control using two-way ANOVA and a p value of <0.05 was assumed statistically significant and denoted by*. Where p>0.05, the lack of statistical significance is denoted by ns.