GSK3 knockin mice exhibit impairments in social preference.

<p>A. Mean total time spent in each chamber during the social preference period. Wild-type (WT) mice (n = 11), but not GSK3 knockin (KI) mice (n = 10), spent significantly more time in Chamber 3 with the novel S2 mouse compared to empty Chamber 2, or to Chamber 1 with the familiar (S1) mouse. * p<0.05 comparing time spent in Chamber 3 with Chambers 1 and 2. B. GSK3 KI mice display deficits in social approach preference, as indicated by no significant difference in the number of nose contacts with S1 or S2. C. The duration of nose contacts with S2 was significantly greater than with S1 for WT, but not GSK3 KI, mice. * p<0.05 comparing WT duration of nose contacts with S1 and S2.