Manhattan plots for eQTL p-values +/− 250Kb of the previously AD associated regions near <i>CLU</i>.

<p>For this plot the x-axis represents the physical region of the chromosome and the y-axis is the –log₁₀ of the asymptotic p-values from the eQTL analyses. The horizontal black dashed line represent the statistically significant threshold based on a Bonferonni correction for the number of SNPs and mRNA transcripts tested, while the black dotted represent the suggestive threshold based on the average number of SNPs tested per transcript. The relative positions of previously disease associated SNPs are denoted by vertical black lines. The individual p-values points for the SNP/Transcript tests are indicated by color and number so that the most significant values are the dark red ‘5’s for SCARA3 and the blue ‘6’s for CCDC25. In the plots the transcripts depicted are not all mRNA transcripts within the region but are instead the transcripts within the region with a probe present on the expression array and was well detected within the sample series.