Experimental model recapitulates the spontaneous abortion and low birth weight outcomes characteristic of PM.

<p><i>(A)</i> Pregnant BALB/c females infected (dark bars) with <i>P. berghei</i> on gestational day (G)13 have an increased rate of abortion and decreased proportion of viable pups per litter compared to uninfected mice (light bars) by G19, day 6 of infection/control injection (D6). Proportion of viable fetuses depicted by solid bars; aborted fetuses, by striped bars. <i>(B)</i> Body weight of viable fetuses is decreased with maternal malaria infection (dark symbols) as compared to weight of fetuses from uninfected mice (light symbols). Dots are individual viable fetuses; bars represent the median of each group. 20–83 fetuses were collected per group (from 4–13 pregnant females per group). *** <i>P</i><0.001 (Mann-Whitney).