The presence of peripheral parasitemia during pregnancy correlates with decreased plasma ANG-1 levels (<i>P</i> = 0.031, mixed linear model).

<p><i>(A)</i> Peripheral plasma ANG-1 levels (± SEM) for uninfected primigravid women who had no detectable peripheral or placental parasitemia during the course of the study (n = 8). <i>(B & C)</i> Peripheral plasma ANG-1 levels from two representative primigravid women with PM. The mean levels for uninfected women are shown as reference (in light shade). Boxed data points represent visits where women were peripheral blood-smear positive for <i>P. falciparum</i>.