<p><b>A</b>) the position of Y116 and C176 are indicated on the ECD structure. Y116 is on the outer convex surface of the LRR3 (red) and C176 (green) is on the concave inner surface of the LRR5. The coordinates for the ectodomain structure of TSH receptor was obtained from the GRIS database <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009449#pone.0009449-Van1" target="_blank">[43]</a> and this structure was examined in the open source molecular graphics program VMD (<a href="http://www.ks.uiuc.edu/Research/vmd" target="_blank">www.ks.uiuc.edu/Research/vmd</a>) to mark the position of Y116 and C176 on the ECD structure. <b>B</b>) Expression of the Y116 on HEK 293 cells is indicated both microscopically and quantitat...
<p>New functional-structural TSHR features at the extracellular site are described for the hinge reg...
<p>The 3D structure of the TSHR ectodomain, based on Sanders et al (20), illustrating the apparently...
<p>Flow cytometric analysis of binding of 25 µg/ml of (<b>9A.</b>) MAb 311.62 or (<b>9B.</b>) MAb 31...
<p><b>Panel A -</b> The source of the native antigen for epitope protection studies was the entire T...
<p>HEK293 cells were transiently transfected with 1 ug of HA or Myc-GPI-TSHR-ecd plasmid cDNA and th...
The thyrotropin stimulating hormone receptor (TSHR) is a G protein coupled receptor (GPCR) with a la...
<p>CHO cells stably expressing GPI-TSHR-ecd were treated with 0, 10 and 1000 µU/ml of bovine TSH for...
<p>(A) COS-7 cells transfected with GFP chimeras of wild-type or TSHR mutants and visualized by fluo...
<div><p>Stimulating, and some blocking, antibodies to the TSH receptor (TSHR) have conformation-depe...
The mechanisms governing transition of the thyroid stimulating hormone (TSH) receptor (TSHR) from ba...
Stimulating, and some blocking, antibodies to the TSH receptor (TSHR) have conformation-dependent ep...
<p>The cytokine and ECDs of the two receptor molecules are colored in the same scheme as in <a href=...
<p>HEK 293 cells transiently transfected with HA-GPI-TSHR-ecd were treated with 0, 10 and 1000 µU/ml...
<p>HA-GPI-TSHR-ecd and myc-GPI-TSHR-ecd were co-transfected into HEK 293 cells and stained with anti...
The thyrotropin receptor (TSHR) cleaves to a variable extent within the ectodomain into a ligand-bin...
<p>New functional-structural TSHR features at the extracellular site are described for the hinge reg...
<p>The 3D structure of the TSHR ectodomain, based on Sanders et al (20), illustrating the apparently...
<p>Flow cytometric analysis of binding of 25 µg/ml of (<b>9A.</b>) MAb 311.62 or (<b>9B.</b>) MAb 31...
<p><b>Panel A -</b> The source of the native antigen for epitope protection studies was the entire T...
<p>HEK293 cells were transiently transfected with 1 ug of HA or Myc-GPI-TSHR-ecd plasmid cDNA and th...
The thyrotropin stimulating hormone receptor (TSHR) is a G protein coupled receptor (GPCR) with a la...
<p>CHO cells stably expressing GPI-TSHR-ecd were treated with 0, 10 and 1000 µU/ml of bovine TSH for...
<p>(A) COS-7 cells transfected with GFP chimeras of wild-type or TSHR mutants and visualized by fluo...
<div><p>Stimulating, and some blocking, antibodies to the TSH receptor (TSHR) have conformation-depe...
The mechanisms governing transition of the thyroid stimulating hormone (TSH) receptor (TSHR) from ba...
Stimulating, and some blocking, antibodies to the TSH receptor (TSHR) have conformation-dependent ep...
<p>The cytokine and ECDs of the two receptor molecules are colored in the same scheme as in <a href=...
<p>HEK 293 cells transiently transfected with HA-GPI-TSHR-ecd were treated with 0, 10 and 1000 µU/ml...
<p>HA-GPI-TSHR-ecd and myc-GPI-TSHR-ecd were co-transfected into HEK 293 cells and stained with anti...
The thyrotropin receptor (TSHR) cleaves to a variable extent within the ectodomain into a ligand-bin...
<p>New functional-structural TSHR features at the extracellular site are described for the hinge reg...
<p>The 3D structure of the TSHR ectodomain, based on Sanders et al (20), illustrating the apparently...
<p>Flow cytometric analysis of binding of 25 µg/ml of (<b>9A.</b>) MAb 311.62 or (<b>9B.</b>) MAb 31...