Plasma angiopoietin levels at delivery are dysregulated in PM and with LBW outcomes.

<p><i>(A–C)</i> Peripheral plasma and <i>(D)</i> matched placental plasma obtained at delivery of normal birth weight (NBW) or LBW infants from primigravid women with (PM+) or without (PM-) PM were measured for ANG-1 and ANG-2 by ELISA. <i>(A)</i> Mean maternal peripheral plasma ANG-1 is elevated with LBW deliveries in PM- but not PM+ women. Statistical analyses by Mann-Whitney test. <i>(B)</i> Maternal peripheral plasma ANG-2 is elevated with PM. Statistical analyses by Mann-Whitney test. <i>(C)</i> Elevated maternal peripheral plasma ANG-2/ANG-1 ratio at delivery is associated with PM (<i>P</i> = 0.0016) and LBW (<i>P</i> = 0.0406); 2-way ANOVA on log-transformed data. Statistical analyses between groups by t-test on log-transformed data. <i>(D)</i> Placental plasma ANG-2/ANG-1 ratio levels are elevated compared to peripheral plasma levels. Statistical analysis by t-test on log-transformed data. Dots represent individual women, lines represent the median of each group. Peripheral plasma, PM- NBW (n = 47), PM- LBW (n = 44), PM+ NBW (n = 51), PM+ LBW (n = 35). Placental plasma, PM- NBW (n = 41), PM- LBW (n = 34), PM+ NBW (n = 44), PM+ LBW (n = 28). * <i>P</i><0.05, ** <i>P</i><0.01, *** <i>P</i><0.001, # <i>P</i> = 0.06, ^∧<i>P</i> = 0.486.