Correlation between clinical score and ability to move and between clinical score and paw grip endurance in CR vs. AL G93A mice.

<p>(A) Relation between clinical score (from clinical onset to euthanasia) and ability to move and (B) between clinical score and paw grip endurance (s) in 23 ad libitum (AL: •, 16 females; ▪, 7 males) and 31 calorie restricted (CR, 60% of ad libitum: ○, 21 females; □, 10 males) G93A mice. For ability to move, slopes and intercepts were not different with the following pooled equation: ability to move = (−1.4) x clinical score + (7.1). For paw grip endurance, data for the females followed a sigmoidal relationship (AL females, r² = 0.990; CR females, r² = 0.995; curves were significantly different, P<0.0001) whereas data for the males followed a linear relationship (slopes were significantly different, P = 0.0011). For AL males (r = −0.984, P<0.0001), paw grip endurance = (−27.8±1.1) x clinical score + (133.5±3.8); for CR males (r = −0.995, P<0.0001), paw grip endurance = (−31.8±0.7) x clinical score + (159.4±2.9), with the data presented as means ± SD. Data are means of each group on the same day.