Motivation for saccharin (sweet) in adult rats exposed to sucrose or water during adolescence.

<p>(A) Percentage of rats reaching the acquisition criterion (>50 reinforcements for 2 consecutive sessions) for saccharin (0.13%, w/v) self-administration; (B) Number of saccharin (0.13%, w/v) reinforcements earned on fixed-ratio 1 (FR1) and fixed-ratio 5 (FR5) schedules; (C) Breakpoint reached during the progressive-ratio (PR) test; and (D) Number of reinforcements earned (FR5) at different saccharin concentrations (in %, w/v), by adult rats exposed to sucrose (N = 15) or water (N = 16) during adolescence. *, **, *** Indicate significant group differences (p<0.05, p<0.01 and p<0.001, respectively).