Paw-swelling.

<p>(A) Comparison of 1mg/kg Etanercept treated vs. the same dose of W89Y/E92N. (B) Comparison of 3mg/kg Etanercept treated vs. the same dose of W89Y/E92N. (C) Comparison of 9mg/kg Etanercept treated vs. the same dose of W89Y/E92N. Arrows indicate the time of treatment. *, **, a significant reduction of paw swelling of W89Y/E92N treatment compared to the groups given Etanercept (P<0.05; P<0.01 student t test). There were 10 rats per group. Black triangle, untreated group; Black diamond, 1mg/kg Etanercept treated group; White diamond, 1mg/kg W89Y/E92N treated group; Black square, 3 mg/kg Etanercept treated group; White square, 3mg/kg W89Y/E92N treated group; Black circle, 9 mg/kg Etanercept treated group; White circle, 9mg/kg W89Y/E92N treated group.