Coiled-coil peptides effectively inhibit RBC hemolysis promoted by EPEC.

<p>(A) Hemolysis of sheep RBC observed with EPEC bacteria preincubated with coiled-coil peptides. Results are presented as percentage relative to hemolysis <b>(±</b> standard deviation) observed upon incubation of RBC with EPEC alone. K12 means the hemolysis caused by the <i>E. coli</i> non-pathogenic strain. (B) Doses-dependent effect of CoilA and CoilB peptides on the hemolysis of RBC. The peptides were applied to the RBC-E2348/69 system to various concentrations and a dose-dependent response was observed. pH represent a mock control to rule out the biological influence of alkaline pH used to dissolve peptides. Each assay was done by triplicate.