Effects of METH self-administration on monoamine levels in the striatum.

<p>METH caused persistent decreases in striatal DA levels (A), which negatively correlated with total drug intake when data at 24 hours, 7 and 14 days after cessation of self-administration were combined (B) and at 14 days post-drug (C). However, only transient changes were found in the levels of NE and 5-HT (D). Data shown as mean ± SEM. *, <i>p</i><0.05; **, <i>p</i><0.01; ***, <i>p</i><0.001 vs control. Data were analyzed by ANOVA followed by PLSD, n = 7−11 per group. Correlation analysis was done by regression analysis.