<p>In response to IR or CDT, MYC contributes to activation of the ATM-dependent responses, leading to induction of apotosis. These pathways are delayed upon MYC homozygote deletion or iRNA-mediated knock down.</p
such as c-myc (Zindy et al., 1998) and ras (Serrano et al., 1997). Activation of this pathway in nor...
Myc is a powerful oncogene frequently deregulated in cancer yet deregulated Myc alone does not lead ...
Myc oncoproteins are commonly activated in malignancies and are sufficient to provoke many types of ...
The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptos...
and otherwise deregulated in numerous and diverse tumor types. These events, which typically lead to...
<p><b>A</b>) HCT116 cells were transfected either with the control GFP-specific (CTR) or MYC specifi...
The transcription factor MYC has fundamental roles in proliferation, apoptosis, tumorigene-sis, and ...
<p>TGR-1, HOmyc3, and HO15.19 cells were left untreated or exposed to IR (20Gy), and further incubat...
Genotoxic or replicative stress triggers a DNA damage response (DDR) that induces cell cycle arrest,...
DNA damage occurs during DNA replication, spontaneous chemical reactions, and assaults by external o...
Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated e...
The cellular DNA damage response (DDR) is initiated by the rapid recruitment of repair factors to th...
Myelocytomatosis oncogene (MYC) family members, including cellular MYC (c-Myc), neuroblastoma derive...
Background: The role of the MYC oncogene in the apoptotic pathways is not fully understood. MYC has ...
SummaryDNA damage activates checkpoint kinases that induce several downstream events, including wide...
such as c-myc (Zindy et al., 1998) and ras (Serrano et al., 1997). Activation of this pathway in nor...
Myc is a powerful oncogene frequently deregulated in cancer yet deregulated Myc alone does not lead ...
Myc oncoproteins are commonly activated in malignancies and are sufficient to provoke many types of ...
The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptos...
and otherwise deregulated in numerous and diverse tumor types. These events, which typically lead to...
<p><b>A</b>) HCT116 cells were transfected either with the control GFP-specific (CTR) or MYC specifi...
The transcription factor MYC has fundamental roles in proliferation, apoptosis, tumorigene-sis, and ...
<p>TGR-1, HOmyc3, and HO15.19 cells were left untreated or exposed to IR (20Gy), and further incubat...
Genotoxic or replicative stress triggers a DNA damage response (DDR) that induces cell cycle arrest,...
DNA damage occurs during DNA replication, spontaneous chemical reactions, and assaults by external o...
Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated e...
The cellular DNA damage response (DDR) is initiated by the rapid recruitment of repair factors to th...
Myelocytomatosis oncogene (MYC) family members, including cellular MYC (c-Myc), neuroblastoma derive...
Background: The role of the MYC oncogene in the apoptotic pathways is not fully understood. MYC has ...
SummaryDNA damage activates checkpoint kinases that induce several downstream events, including wide...
such as c-myc (Zindy et al., 1998) and ras (Serrano et al., 1997). Activation of this pathway in nor...
Myc is a powerful oncogene frequently deregulated in cancer yet deregulated Myc alone does not lead ...
Myc oncoproteins are commonly activated in malignancies and are sufficient to provoke many types of ...