Tumor onset is accelerated in TRAMP mice lacking iNKT cells.

<p>Age- and sex-matched male TRAMP (white bars; n = 97), TRAMPJα18^−/− (black bars; n = 51) and WT mice (gray bars; n = 97) were killed at the indicated week after birth and the anatomy and histology of the UGA was analyzed as indicated in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008646#s2" target="_blank">Material and Methods</a> section. Animals affected by neuroendocrine tumors were excluded. A, UGA weight (g), expressed as average±SEM, of TRAMP, TRAMPJα18^−/− and WT mice killed at weeks 6–8 (n = 5, 8 and 19, respectively), 12–16 (n = 16, 17 and 26), 17–24 (n = 30, 15 and 26) and 25–28 (n = 46, 11 and 26), respectively. B, ratio of the weight of UGA and body weight subtracted of the UGA in the groups of animals reported above. C, Disease score, expressed as average±SEM, of the groups of animals reported above. Statistical analysis of collected data was performed using the Student's <i>t</i>-test (A and B) and the Mann-Whitney test (C); ***p<0.001, **0.001