<p>(A) B cell numbers following CY or PBS treatment. Flow cytometry was performed to identify B (B220<sup>+</sup>) cells and the Tg (IgG2b+) B cells. The B cell numbers from individual mice is represented. A significant decrease in total B cell numbers in both the BALB/c WT mice as well as the BALB/c R4A Tg mice following CY treatment was observed at all time points analyzed, but was near normal by day 28. (B) Lymphocyte numbers following CY or PBS treatment. Flow cytometry was performed to identify B (B220<sup>+</sup>) cells and T (CD3<sup>+</sup>) cells. A representative dot plot is shown.</p
<p>Draining lymph nodes were collected the mice of 5 days after the DNFB or vehicle application mice...
<p>Flow cytometry was performed on cells prepared from SMGs from male <i>Myd88</i><sup>+/+</sup> mic...
<p>Following infection with V and Ts, the spleen (A), MLN and blood from three mice per group per ti...
<p><i>n</i> = 4–5 mice per group. Data are presented as the mean±SD.</p><p>Tg+ B cells were reconsti...
<p><i>n</i> = 4–5 mice per group. Data are presented as the mean±SD.</p>*<p>denotes that the compari...
<p>The markers B220 and AA4.1 were used to differentiate mature (B220<sup>+</sup>/AA4.1<sup>−</sup>)...
<p>Mice were treated with SU5416 (25 mg/kg/day) or equivalent amounts of vehicle. In separate experi...
<p><i>n</i> = 5 mice per group. Data are presented as the mean±SD.</p>*<p>denotes that the compariso...
<p>A. Flow cytometric analysis of lymphocytes in the spleen and LNs of control and mutant mice. Pool...
<p>Data are presented as the frequency of Tg+ B cells expressing Vk1a/Jk1 or Jk4 out of the total nu...
<p>Five BALB/c mice were treated with CY and five with PBS. Student's t test was used to determine t...
<p>After TM injection at PN4, control (n = 3) and Jak2 cKO (n = 4) spleens were harvested at PN15 an...
<p>Data are presented as the frequency of Tg+ B cells expressing Vk1a/Jk1 or Jk4 out of the total nu...
<p>(A) Diagrammatic representation of experiment protocol. BALB/c mice were immunized with SRBC on d...
<p>CFSE-labeled OT-II cells (5×10<sup>6</sup>) were i.v. injected into recipient C57BL/6 mice. One d...
<p>Draining lymph nodes were collected the mice of 5 days after the DNFB or vehicle application mice...
<p>Flow cytometry was performed on cells prepared from SMGs from male <i>Myd88</i><sup>+/+</sup> mic...
<p>Following infection with V and Ts, the spleen (A), MLN and blood from three mice per group per ti...
<p><i>n</i> = 4–5 mice per group. Data are presented as the mean±SD.</p><p>Tg+ B cells were reconsti...
<p><i>n</i> = 4–5 mice per group. Data are presented as the mean±SD.</p>*<p>denotes that the compari...
<p>The markers B220 and AA4.1 were used to differentiate mature (B220<sup>+</sup>/AA4.1<sup>−</sup>)...
<p>Mice were treated with SU5416 (25 mg/kg/day) or equivalent amounts of vehicle. In separate experi...
<p><i>n</i> = 5 mice per group. Data are presented as the mean±SD.</p>*<p>denotes that the compariso...
<p>A. Flow cytometric analysis of lymphocytes in the spleen and LNs of control and mutant mice. Pool...
<p>Data are presented as the frequency of Tg+ B cells expressing Vk1a/Jk1 or Jk4 out of the total nu...
<p>Five BALB/c mice were treated with CY and five with PBS. Student's t test was used to determine t...
<p>After TM injection at PN4, control (n = 3) and Jak2 cKO (n = 4) spleens were harvested at PN15 an...
<p>Data are presented as the frequency of Tg+ B cells expressing Vk1a/Jk1 or Jk4 out of the total nu...
<p>(A) Diagrammatic representation of experiment protocol. BALB/c mice were immunized with SRBC on d...
<p>CFSE-labeled OT-II cells (5×10<sup>6</sup>) were i.v. injected into recipient C57BL/6 mice. One d...
<p>Draining lymph nodes were collected the mice of 5 days after the DNFB or vehicle application mice...
<p>Flow cytometry was performed on cells prepared from SMGs from male <i>Myd88</i><sup>+/+</sup> mic...
<p>Following infection with V and Ts, the spleen (A), MLN and blood from three mice per group per ti...