Incidence and latency of reproductive tract tumors in female mice with conditional inactivation of LoxP flanked alleles of <i>Brca1</i> and/or <i>p53</i>.

<p>A) Fraction of tumor free mice after intrabursal injection of Adenovirus-Cre recombinase. B) Genotyping analysis of DNA isolated from <i>Brca1</i>^Δ5-13;<i>p53</i>^Δ2-10 and <i>p53^Δ2-10</i> ovarian tumors. Both the Lox P flanked and excised <i>Brca1</i> and <i>p53</i> alleles were amplified from <i>Brca1</i>^Δ5-13;<i>p53</i>^Δ2-10 tumors (cases 307, 350, 352 355, 397, 399, 411 and 412) and the Lox P flanked and excised <i>p53</i> allele was amplified from the single <i>p53^Δ2-10</i> ovarian tumor (case 627). In each panel the left lane contains a DNA ladder and the sizes of the amplified products (nt) are indicated at the right.