Hindpaw inflammatory swelling is reduced in juveniles and adults fed the ketogenic diet.

<p>Control diet – filled symbols, ketogenic diet – empty symbols for juveniles (<i>left</i>) and adults (<i>right</i>). Hindpaw volumes are shown as right/left ratios, measured just prior to and 48 h after injection of CFA into the right hindpaw. As expected, baseline ratios are similar to 1.0 in all groups. CFA-induced swelling was similar in juvenile and adult rats (71% and 72%, respectively), and was attenuated significantly by the ketogenic diet in both age groups. Analysis of juveniles indicated a significant effect of CFA (F = 68.7, p<0.001), and a significant diet x CFA interaction (F = 5.4, p<0.05). Analysis of adults indicated significant effects of CFA (F = 183.6, p<0.001) and a significant diet x CFA interaction (F = 7.5, p<0.05). Numbers of subjects: 7 for juvenile control diet, 6 for juvenile ketogenic diet, 12 for adult control diet, 11 for adult ketogenic diet. * p<0.05, *** p<0.001 Newman-Keuls comparisons to post-CFA controls.