Greater cancellous bone volume and formation in <i>NPY ^−/−</i> mice.

<p>Histomorphometric analysis of distal femoral metaphysis in male mice showing (a) cancellous bone volume, (b) bone formation rate, (c) mineralizing surface, (d) mineral apposition rate, (e) osteoclast surface and (f) osteoclast number. (g) Representative micro-computed tomographs of the distal femoral metaphysis of 4 month old male wild type and <i>NPY ^−/−</i> mice. (h) 4th lumbar vertebral sections from male wild type and <i>NPY ^−/−</i> mice, displaying greater cancellous bone volume (BV/TV) in mutant mice. # p<0.05 vs wild type. n = 8−14, data expressed as mean±SE.