Performance of different classification methods.

<p>The bar charts show the average AUCs for different classification methods. Five pathway-based methods that use distinct pathway activity inference schemes (LLR, CORG, PCA, mean, and median) and a gene-based method were compared. (A) Classifiers were constructed based on logistic regression. Results of within-dataset experiments based on the USA and Netherlands datasets are shown in the two charts on the left. The two charts on the right show the results of the cross-dataset experiments. (B) The performance of different classification methods based on LDA (linear discriminant analysis).