Greater coherence increases potentiation.

<p>The top panel in each subfigure shows a raster plot with spikes from each of 3 inputs (red, green, and purple) and spikes from the E cell (blue). The input spikes are randomly distributed with a variance of about the mean ISI. The time axis is enlarged to show detail. Second panels are total AMPAR conductance. Third panels are AMPAR conductance for each synapse for each individual input, rescaled. Bottom panels are NMDAR current open probabilities for each input. (A) C = 0.99 resulted in prolonged potentiation for this simulation with 3 inputs. (B) C = 0.10 resulted in diminished, brief potentiation, since input ISIs were still in a potentiating regime but not coherent.