Misexpression of <i>Dlx5</i> in chondrocytes accelerated chondrocyte hypertrophy.

<p>(A,B) Haematoxylin and eosin (H&E) staining of coronal sections of the head of wild type (A) and <i>Col2a1-Dlx5</i> transgenic (B) E16.5 embryos. Arrows point to proliferating zones in panel A. Dorsal is up. (C,D) Alizarin red-stained and cleared vertebral columns of wild type (C) and transgenic (D) P1 embryos were embedded in paraffin and sectioned. Arrows point to cartilaginous tissue in panel C. Boxed region is shown at higher magnification in panel C insert. Dorsal is up. (E,F) H&E stained longitudinal sections through the proximal humerus of wild type (E) and transgenic littermate (F). Proximal is up. Scale bar = 0.2 mm in A,B,E,F, 2 mm in C,D.