Donor specific blood transfusion (DST) induces tolerance to liver allografts.

<p><b>LEW rats were pretreated with 1 ml of heparinized DA blood (DST) once per week for 4 weeks prior to DA liver transplantation (LTx).</b> LTx was performed 7 days following last DST treatment (DSTx4+LTx 7days; black squares, n = 10). DSTx4+LTx 37days (white squares, n = 5) and DSTx4+LTx 107days (white diamonds, n = 4) represent LEW rats pretreated once per week for 4 weeks with DST with LTx performed at 37 or 107 days following last DST treatment. Some animals did not receive DST but did receive LTx (black triangles, n = 7). *P<0.05 compared with LTx alone.