Acceleration of diabetes incidence in CD28^−/− NOD mice following administration of anti-GITR antibody.

<p>(A) Ten day-old female CD28^−/− NOD mice (n = 8) were treated with anti-GITR antibody or purified Igs. The dose used was 0.8 mg/injection/mouse i.p. once a week on d10, d17 and d24 of life. Anti-GITR antibody treatment significantly exacerbated diabetes onset in all animals used (p<0.007). (B) Histological analysis of pancreas recovered from 9-week-old female CD28^−/− NOD mice injected with anti-GITR antibody or control Igs. Invasive insulitis was clearly worsened in anti-GITR-treated animals (p<0.011).