Both 15d-PGJ2 and rosiglitazone suppressed IPP-stimulated Vδ2 T cell proliferation.

<p>Fresh isolated PBMC was treated with 15d-PGJ2 (A) or rosiglitazone (B) at various concentrations (µM) for 1 hour, and then stimulated with IPP (15 µM) plus IL2 (100U/ml). Cells were cultured for 10 days by adding IL2 every 3 days. Vδ2 T cell frequency was detected every 3 day. The experiments were set in triplicate. The statistical significance compared with drug vehicle (DMSO) control was analyzed. *, P<0.05; **, P<0.01; ***, P<0.001. Data are representative of at least three independent experiments with different donors.