Comparison of the SAA1 α homozygous genotype frequencies in Armenian and Karabakhian FMF patients.

Involvement of the Modifier Gene of a Human Mendelian Disorder in a Negative Selection Process

Hasmik Hayrapetyan
Emmanuelle Cochet
Jean-louis Serre
Josue ́ Feingold
Gilles Grateau
Tamara Sarkisian
Marc Jeanpierre
Serge Amselem

August 2016

Background: Identification of modifier genes and characterization of their effects represent major c...

Comparison of the FMF prevalence estimated on clinical reports to the prevalence calculated from the frequency of mutated MEFV alleles.

Isabelle Jéru (369567)
Véronique Hentgen (430312)
Emmanuelle Cochet (369569)
Philippe Duquesnoy (65332)
Gaëlle Le Borgne (430313)
Emmanuel Grimprel (430314)
Katia Stankovic Stojanovic (430315)
Sonia Karabina (430316)
Gilles Grateau (369571)
Serge Amselem (65335)

July 2013

P: FMF prevalence; q: frequency of mutated MEFV allele; p: frequency of normal MEFV...

The AFP level of the homozygous Arg/Arg genotype of FGFR4 rs351855 compared with that of the Gly/Gly genotype (p = 0.018).

Ming-Jen Sheu (692889)
Ming-Ju Hsieh (184855)
Whei-Ling Chiang (546747)
Shun-Fa Yang (155103)
Hsiang-Lin Lee (456689)
Liang-Ming Lee (457879)
Chao-Bin Yeh (184853)

April 2015

The AFP level of the homozygous Arg/Arg genotype of FGFR4 rs351855 compared with that of the Gly/...

Comparison of the MEFV p.Met694Val homozygous genotype frequencies in Armenian and Karabakhian FMF patients.

Isabelle Jéru (369567)
Hasmik Hayrapetyan (369568)
Philippe Duquesnoy (65332)
Emmanuelle Cochet (369569)
Jean-Louis Serre (369570)
Josué Feingold (76775)
Gilles Grateau (369571)
Tamara Sarkisian (369572)
Marc Jeanpierre (369573)
Serge Amselem (65335)

February 2013

Comparison of the MEFV p.Met694Val homozygous genotype frequencies in Armenian and Karabak...

SAA1 genotype and allele distributions in Armenian and Karabakhian FMF patients and controls.

Isabelle Jéru (369567)
Hasmik Hayrapetyan (369568)
Philippe Duquesnoy (65332)
Emmanuelle Cochet (369569)
Jean-Louis Serre (369570)
Josué Feingold (76775)
Gilles Grateau (369571)
Tamara Sarkisian (369572)
Marc Jeanpierre (369573)
Serge Amselem (65335)

February 2013

A. Genotype frequencies. B. Allele frequencies. Ar = Armenia, K = Karabakh. o stands for “other a...

Allele frequencies of SAA1 gene polymorphisms in typical and incomplete FMF patients.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

Allele frequencies of SAA1 gene polymorphisms in typical and incomplete FMF patients.</p

Frequencies of the genotypes and alleles at the SAA1 locus of Japanese patients with FMF and healthy subjects.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

SAA1; Serum amyloid A1. Chi-square test was used to examine differences of genotype and al...

Frequencies of the genotypes and alleles at -13C/T SAA1 locus of Japanese patients with FMF and healthy subjects.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

SAA1; Serum amyloid A1. Chi-square test was used to examine differences of genotype and al...

Comparison of SAA1 genotype distributions to sampling fluctuations in populations under the assumption of HWE.

Isabelle Jéru (369567)
Hasmik Hayrapetyan (369568)
Philippe Duquesnoy (65332)
Emmanuelle Cochet (369569)
Jean-Louis Serre (369570)
Josué Feingold (76775)
Gilles Grateau (369571)
Tamara Sarkisian (369572)
Marc Jeanpierre (369573)
Serge Amselem (65335)

February 2013

A. Comparison in Armenian patients. A Monte Carlo algorithm was used to represent the data from 1...

Number of MEFV gene mutations and SAA1 gene polymorphisms in FMF patients.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

Number of MEFV gene mutations and SAA1 gene polymorphisms in FMF patients.</...

Comparison of the ratio [heterozygous carriers/non carriers] (R = 2pq/p2) observed in genetically-unexplained FMF patients and expected in several origin-matched populations.

Isabelle Jéru (369567)
Véronique Hentgen (430312)
Emmanuelle Cochet (369569)
Philippe Duquesnoy (65332)
Gaëlle Le Borgne (430313)
Emmanuel Grimprel (430314)
Katia Stankovic Stojanovic (430315)
Sonia Karabina (430316)
Gilles Grateau (369571)
Serge Amselem (65335)

July 2013

aq frequencies used to calculate R ratios in general control populations were taken from previous...

Frequencies of SAA1 -13C/T, SAA2, IL1β -511 genotypes in Japanese patients with FMF and frequencies of SAA1 -13C/T, SAA2, IL1β -511 genotypes in healthy subjects.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

aExpected genotype frequencies based on observed allele frequencies and assuming Hardy-Weinberg e...

Heterozygotes: A Statistical Approach

Jéru Isabelle
Hentgen Véronique
Cochet Emmanuelle
Duquesnoy Philippe
Le Borgne Gaëlle
Grimprel Emmanuel
Stojanovic Katia Stankovic
Karabina Sonia
Grateau Gilles
Amselem Serge

July 2013

mutations and one of the most frequent Mediterranean genetic diseases. The observation of many hete...

Involvement of the modifier gene of a human Mendelian disorder in a negative selection process.

Isabelle Jéru
Hasmik Hayrapetyan
Philippe Duquesnoy
Emmanuelle Cochet
Jean-Louis Serre
Josué Feingold
Gilles Grateau
Tamara Sarkisian
Marc Jeanpierre
Serge Amselem

October 2009

BACKGROUND:Identification of modifier genes and characterization of their effects represent major ch...

Frequencies of the genotypes at the IL-1β -511, IL-1Ra and SAA2 loci in patients with FMF and healthy subjects.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

IL-1β; Interleukin-1β .IL-1Ra; Interleukin-1 receptor antagonist .SAA2; Seru...

Involvement of the Modifier Gene of a Human Mendelian Disorder in a Negative Selection Process

Hasmik Hayrapetyan
Emmanuelle Cochet
Jean-louis Serre
Josue ́ Feingold
Gilles Grateau
Tamara Sarkisian
Marc Jeanpierre
Serge Amselem

August 2016

Background: Identification of modifier genes and characterization of their effects represent major c...

Comparison of the FMF prevalence estimated on clinical reports to the prevalence calculated from the frequency of mutated MEFV alleles.

Isabelle Jéru (369567)
Véronique Hentgen (430312)
Emmanuelle Cochet (369569)
Philippe Duquesnoy (65332)
Gaëlle Le Borgne (430313)
Emmanuel Grimprel (430314)
Katia Stankovic Stojanovic (430315)
Sonia Karabina (430316)
Gilles Grateau (369571)
Serge Amselem (65335)

July 2013

P: FMF prevalence; q: frequency of mutated MEFV allele; p: frequency of normal MEFV...

The AFP level of the homozygous Arg/Arg genotype of FGFR4 rs351855 compared with that of the Gly/Gly genotype (p = 0.018).

Ming-Jen Sheu (692889)
Ming-Ju Hsieh (184855)
Whei-Ling Chiang (546747)
Shun-Fa Yang (155103)
Hsiang-Lin Lee (456689)
Liang-Ming Lee (457879)
Chao-Bin Yeh (184853)

April 2015

The AFP level of the homozygous Arg/Arg genotype of FGFR4 rs351855 compared with that of the Gly/...

Comparison of the MEFV p.Met694Val homozygous genotype frequencies in Armenian and Karabakhian FMF patients.

Isabelle Jéru (369567)
Hasmik Hayrapetyan (369568)
Philippe Duquesnoy (65332)
Emmanuelle Cochet (369569)
Jean-Louis Serre (369570)
Josué Feingold (76775)
Gilles Grateau (369571)
Tamara Sarkisian (369572)
Marc Jeanpierre (369573)
Serge Amselem (65335)

February 2013

Comparison of the MEFV p.Met694Val homozygous genotype frequencies in Armenian and Karabak...

SAA1 genotype and allele distributions in Armenian and Karabakhian FMF patients and controls.

Isabelle Jéru (369567)
Hasmik Hayrapetyan (369568)
Philippe Duquesnoy (65332)
Emmanuelle Cochet (369569)
Jean-Louis Serre (369570)
Josué Feingold (76775)
Gilles Grateau (369571)
Tamara Sarkisian (369572)
Marc Jeanpierre (369573)
Serge Amselem (65335)

February 2013

A. Genotype frequencies. B. Allele frequencies. Ar = Armenia, K = Karabakh. o stands for “other a...

Allele frequencies of SAA1 gene polymorphisms in typical and incomplete FMF patients.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

Allele frequencies of SAA1 gene polymorphisms in typical and incomplete FMF patients.</p

Frequencies of the genotypes and alleles at the SAA1 locus of Japanese patients with FMF and healthy subjects.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

SAA1; Serum amyloid A1. Chi-square test was used to examine differences of genotype and al...

Frequencies of the genotypes and alleles at -13C/T SAA1 locus of Japanese patients with FMF and healthy subjects.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

SAA1; Serum amyloid A1. Chi-square test was used to examine differences of genotype and al...

Comparison of SAA1 genotype distributions to sampling fluctuations in populations under the assumption of HWE.

Isabelle Jéru (369567)
Hasmik Hayrapetyan (369568)
Philippe Duquesnoy (65332)
Emmanuelle Cochet (369569)
Jean-Louis Serre (369570)
Josué Feingold (76775)
Gilles Grateau (369571)
Tamara Sarkisian (369572)
Marc Jeanpierre (369573)
Serge Amselem (65335)

February 2013

A. Comparison in Armenian patients. A Monte Carlo algorithm was used to represent the data from 1...

Number of MEFV gene mutations and SAA1 gene polymorphisms in FMF patients.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

Number of MEFV gene mutations and SAA1 gene polymorphisms in FMF patients.</...

Comparison of the ratio [heterozygous carriers/non carriers] (R = 2pq/p2) observed in genetically-unexplained FMF patients and expected in several origin-matched populations.

Isabelle Jéru (369567)
Véronique Hentgen (430312)
Emmanuelle Cochet (369569)
Philippe Duquesnoy (65332)
Gaëlle Le Borgne (430313)
Emmanuel Grimprel (430314)
Katia Stankovic Stojanovic (430315)
Sonia Karabina (430316)
Gilles Grateau (369571)
Serge Amselem (65335)

July 2013

aq frequencies used to calculate R ratios in general control populations were taken from previous...

Frequencies of SAA1 -13C/T, SAA2, IL1β -511 genotypes in Japanese patients with FMF and frequencies of SAA1 -13C/T, SAA2, IL1β -511 genotypes in healthy subjects.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

aExpected genotype frequencies based on observed allele frequencies and assuming Hardy-Weinberg e...

Heterozygotes: A Statistical Approach

Jéru Isabelle
Hentgen Véronique
Cochet Emmanuelle
Duquesnoy Philippe
Le Borgne Gaëlle
Grimprel Emmanuel
Stojanovic Katia Stankovic
Karabina Sonia
Grateau Gilles
Amselem Serge

July 2013

mutations and one of the most frequent Mediterranean genetic diseases. The observation of many hete...

Involvement of the modifier gene of a human Mendelian disorder in a negative selection process.

Isabelle Jéru
Hasmik Hayrapetyan
Philippe Duquesnoy
Emmanuelle Cochet
Jean-Louis Serre
Josué Feingold
Gilles Grateau
Tamara Sarkisian
Marc Jeanpierre
Serge Amselem

October 2009

BACKGROUND:Identification of modifier genes and characterization of their effects represent major ch...

Frequencies of the genotypes at the IL-1β -511, IL-1Ra and SAA2 loci in patients with FMF and healthy subjects.

Kiyoshi Migita (290200)
Kazunaga Agematsu (398352)
Junya Masumoto (277060)
Hiroaki Ida (398356)
Seiyo Honda (398360)
Yuka Jiuchi (398363)
Yasumori Izumi (398365)
Yumi Maeda (172420)
Ritei Uehara (398367)
Yoshikazu Nakamura (7025)
Tomohiro Koga (398369)
Atsushi Kawakami (398370)
Munetoshi Nakashima (398371)
Yuichiro Fujieda (398372)
Fumiaki Nonaka (398373)
Katsumi Eguchi (398374)
Hiroshi Furukawa (290179)
Tadashi Nakamura (323696)
Minoru Nakamura (398375)
Michio Yasunami (201944)

February 2013

IL-1β; Interleukin-1β .IL-1Ra; Interleukin-1 receptor antagonist .SAA2; Seru...

Involvement of the Modifier Gene of a Human Mendelian Disorder in a Negative Selection Process

Hasmik Hayrapetyan
Emmanuelle Cochet
Jean-louis Serre
Josue ́ Feingold
Gilles Grateau
Tamara Sarkisian
Marc Jeanpierre
Serge Amselem

August 2016

Background: Identification of modifier genes and characterization of their effects represent major c...

Comparison of the FMF prevalence estimated on clinical reports to the prevalence calculated from the frequency of mutated MEFV alleles.

Isabelle Jéru (369567)
Véronique Hentgen (430312)
Emmanuelle Cochet (369569)
Philippe Duquesnoy (65332)
Gaëlle Le Borgne (430313)
Emmanuel Grimprel (430314)
Katia Stankovic Stojanovic (430315)
Sonia Karabina (430316)
Gilles Grateau (369571)
Serge Amselem (65335)

July 2013

P: FMF prevalence; q: frequency of mutated MEFV allele; p: frequency of normal MEFV...

The AFP level of the homozygous Arg/Arg genotype of FGFR4 rs351855 compared with that of the Gly/Gly genotype (p = 0.018).

Ming-Jen Sheu (692889)
Ming-Ju Hsieh (184855)
Whei-Ling Chiang (546747)
Shun-Fa Yang (155103)
Hsiang-Lin Lee (456689)
Liang-Ming Lee (457879)
Chao-Bin Yeh (184853)

April 2015

The AFP level of the homozygous Arg/Arg genotype of FGFR4 rs351855 compared with that of the Gly/...

Comparison of the <i>SAA1</i> α homozygous genotype frequencies in Armenian and Karabakhian FMF patients.

Abstract

Extracted data

Comparison of the <i>SAA1</i> α homozygous genotype frequencies in Armenian and Karabakhian FMF patients.

Abstract

Extracted data

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