The T cell response to CVS-F3 infection in the absence of B cells mediates enhanced BBB permeability and long-term survival.

<p>The extent of BBB permeability in the cerebellum of wild-type, JHD^−/− and RAG-2^−/− mice, infected i.n. with CVS-F3 10 days previously, is shown in panel A. Weight loss over the course of infection in JHD^−/− and RAG-2^−/− mice is shown in panel B, while the number of copies of rabies virus nucleoprotein mRNA at different times of infection in these animals is presented in panel C. BBB permeability changes are shown as the mean±S.E.M. fold increase in Na-Fluorescein uptake in the tissues with the levels from uninfected mice taken as 1. Weight is expressed as the mean±S.E.M. percent body weight with the weight on day 0 being taken as 100% and copies of nucleoprotein mRNA in the tissues are expressed per copy of L13 mRNA in the same sample.