The administration of rabies virus neutralizing antibodies fails to clear CVS-F3 from the CNS of JHD^−/− mice.

<p>JHD ^−/− mice were infected i.n. with CVS-F3 and treated at 7, 9, 11, 13, and 15 days post-infection with saline vehicle alone or the rabies-specific antibody 1112. Three weeks after the final treatment mice were transcardially perfused, cerebellar tissues were removed, and virus replication was estimated by quantifying nucleoprotein mRNA levels. Virus replication was similarly estimated in cerebellar tissues from wild-type mice infected with CVS-F3 24 days previously. Virus replication is expressed as the mean±S.E.M. copies of rabies virus nucleoprotein mRNA per copy of the housekeeping gene L13 mRNA in the tissue sample.