I_Cl in human cardiac fibroblasts.

<p>A. Voltage-dependent current was inhibited by the Cl⁻ channel blocker DIDS (150 µM). Current was elicited by the voltage steps as shown in the <i>inset</i> (0.2 Hz). <i>B. </i><i> I-V</i> relation curve of DIDS-sensitive current obtained by subtracting currents before and after DIDS application in A. <i>C.</i> Voltage-dependent current recorded in a representative cells during control, after 20 min 0.7T exposure and application of 100 µM NPPB. <i>D.</i><i> I-V</i> relationships for control current (1.0T), 0.7T and 0.7T with 100 µM NPPB. The 0.7T-induced current was significantly inhibited by NPPB at all test potentials (n<i> = </i>5, P<0.01). The arrows in the figure indicate the zero current level.