<p>The mRNA levels for genes encoding antioxidant proteins (<i>A</i>). The mRNA levels for genes encoding proteins instrumental in the production of the antioxidant cofactor NADPH (<i>B</i>). Intra-insular reduced glutathione GSH (Eq GSH) content was higher in GK/Par than Wistar rats (<i>C</i>). Data are the means±SEM of 8–16 experiments in each group. *<i>p</i><0.05 <i>vs.</i> age-matched Wistar group.</p
Aims/hypothesis We determined whether high-glucose-induced beta cell dysfunction is associated with ...
The goal of this study was to examine the influence of exercise training and type I diabetes on the ...
<p>Total RNA was extracted from freshly isolated islets of 2.5-month-old male Wistar and GK rats and...
<p>Protocols (see the legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pon...
BACKGROUND:Oxidative stress (OS), through excessive and/or chronic reactive oxygen species (ROS), is...
Background Oxidative stress (OS), through excessive and/or chronic reactive oxygen species (ROS), is...
Islet-level oxidative stress has been proposed as a trigger for type 1 diabetes (T1D), and release o...
Oxidative stress (OS), through excessive and/or chronic reactive oxygen species (ROS), is a mediator...
<p>(A) Measurement of Cu/Zn-superoxide dismutase (SOD1) and (B) gluthathione peroxidase (Gpx1) mRNA ...
<p>ROS generation was assessed as CM-H<sub>2</sub>DCFDA fluorescence intensity (arbitrary units (AU)...
National audienceIn the adult GK rat, a spontaneous model of type 2 diabetes, total pancreatic β-cel...
<div><p>Mitochondria and NADPH oxidase are important sources of reactive oxygen species in particula...
<p>Wistar or GK/Par islets were perifused with medium containing (in mmol/l) 2.8 glucose (G2.8), 16....
Islets from adult rat possess weak antioxidant defense leading to unbalance between superoxide dismu...
Exposure to high glucose concentrations increases the mRNA levels of oxygen radical scav- enging enz...
Aims/hypothesis We determined whether high-glucose-induced beta cell dysfunction is associated with ...
The goal of this study was to examine the influence of exercise training and type I diabetes on the ...
<p>Total RNA was extracted from freshly isolated islets of 2.5-month-old male Wistar and GK rats and...
<p>Protocols (see the legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pon...
BACKGROUND:Oxidative stress (OS), through excessive and/or chronic reactive oxygen species (ROS), is...
Background Oxidative stress (OS), through excessive and/or chronic reactive oxygen species (ROS), is...
Islet-level oxidative stress has been proposed as a trigger for type 1 diabetes (T1D), and release o...
Oxidative stress (OS), through excessive and/or chronic reactive oxygen species (ROS), is a mediator...
<p>(A) Measurement of Cu/Zn-superoxide dismutase (SOD1) and (B) gluthathione peroxidase (Gpx1) mRNA ...
<p>ROS generation was assessed as CM-H<sub>2</sub>DCFDA fluorescence intensity (arbitrary units (AU)...
National audienceIn the adult GK rat, a spontaneous model of type 2 diabetes, total pancreatic β-cel...
<div><p>Mitochondria and NADPH oxidase are important sources of reactive oxygen species in particula...
<p>Wistar or GK/Par islets were perifused with medium containing (in mmol/l) 2.8 glucose (G2.8), 16....
Islets from adult rat possess weak antioxidant defense leading to unbalance between superoxide dismu...
Exposure to high glucose concentrations increases the mRNA levels of oxygen radical scav- enging enz...
Aims/hypothesis We determined whether high-glucose-induced beta cell dysfunction is associated with ...
The goal of this study was to examine the influence of exercise training and type I diabetes on the ...
<p>Total RNA was extracted from freshly isolated islets of 2.5-month-old male Wistar and GK rats and...