<p>Proportion of 10,000 datasets simulated under the null hypothesis of no genotyping error and in the presence of LD such that . Columns 2 through 5 display results for various chip sizes when generating minor allele frequencies from a Uniform (0.1,0.5) distribution. Columns 6 through 9 display analogous results when generating minor allele frequencies from a Beta (2,8) distribution. Each row depicts results corresponding to a distinct genotyping error model from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000572#pgen-1000572-g001" target="_blank">Figure 1</a>.</p
Two-point linkage analyses of whole genome sequence data are a promising approach to identify rare v...
<div><p>(A) The graph shows average values of |D′| and their confidence limits (± standard deviation...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...
<p>Average standardized transmission test over 1,000 replications for varying levels of genotype err...
<p>Average standardized transmission test over 1,000 replications for varying levels of genotype err...
<p>The true positive rate (TPR, row 1), false discovery rate (FDR, row 2) and false positive rate (F...
SummaryOne of the major challenges facing genome-scan studies to discover disease genes is the asses...
<p>Shown is the true positive rate as a function of false positive rate for correct identification o...
<p>(a) From our simulated case-control studies, we randomly-sampled markers in order to mimic the as...
<p>The true positive rate (TPR, row 1), false discovery rate (FDR, row 2) and false positive rate (F...
An increasing number of genome-wide association studies are being performed in hundreds of thousands...
<p>Power is shown at a false discovery rate of 5% for 50 replicate simulations based on 650,000 mark...
There is great current interest in using linkage disequilibrium (LD)-based genome screens to localiz...
<p>Each plot presents results for one simulation scenario (5/10K 10 thousand LD blocks with 5 loci e...
<p>Box plots indicate the posterior predictive distributions for each locus (1,000 replicates; horiz...
Two-point linkage analyses of whole genome sequence data are a promising approach to identify rare v...
<div><p>(A) The graph shows average values of |D′| and their confidence limits (± standard deviation...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...
<p>Average standardized transmission test over 1,000 replications for varying levels of genotype err...
<p>Average standardized transmission test over 1,000 replications for varying levels of genotype err...
<p>The true positive rate (TPR, row 1), false discovery rate (FDR, row 2) and false positive rate (F...
SummaryOne of the major challenges facing genome-scan studies to discover disease genes is the asses...
<p>Shown is the true positive rate as a function of false positive rate for correct identification o...
<p>(a) From our simulated case-control studies, we randomly-sampled markers in order to mimic the as...
<p>The true positive rate (TPR, row 1), false discovery rate (FDR, row 2) and false positive rate (F...
An increasing number of genome-wide association studies are being performed in hundreds of thousands...
<p>Power is shown at a false discovery rate of 5% for 50 replicate simulations based on 650,000 mark...
There is great current interest in using linkage disequilibrium (LD)-based genome screens to localiz...
<p>Each plot presents results for one simulation scenario (5/10K 10 thousand LD blocks with 5 loci e...
<p>Box plots indicate the posterior predictive distributions for each locus (1,000 replicates; horiz...
Two-point linkage analyses of whole genome sequence data are a promising approach to identify rare v...
<div><p>(A) The graph shows average values of |D′| and their confidence limits (± standard deviation...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...