High arginase activity is localised at the site of pathology and results in reduced levels of L-arginine at the site of pathology.

<p>(A) Groups of BALB/c and CBA mice (n = 4) were infected with <i>L. major</i> parasites in one hind footpad and 1, 4 and 6 weeks post infection, individual footpads and popliteal lymph nodes were harvested and arginase activity was determined by enzymatic assay. Each symbol represents arginase activity for one individual organ, the horizontal line representing the average value. Data show the results of one representative experiment out of five independent experiments. (B) Groups of BALB/c and CBA mice (n = 4) were infected with <i>L. major</i> parasites in one hind footpad and 4 weeks post infection, individual footpads and popliteal lymph nodes were harvested and levels of extracellular L-arginine were determined using an amino acid analyser. Data show the results of one representative experiment out of two independent experiments.