Boric acid inhibits Ca²⁺ release in response to ryanodine receptor agonist 4-CmC (50 µM) in DU-145 cells.

<p>A. Consecutive applications of 4-CmC did not alter the calcium release response (n = 6, NS). B. 0.1 µM BA did not inhibit Ca²⁺ release. C. 1.0 µM BA inhibited Ca²⁺ release (n = 6, *p<0.05). D. 10 µM BA inhibited Ca²⁺ release (n = 6, ***p = 0.0005). E. Combined data analysis showing a dose dependent Ca²⁺ release response (n = 6 per concentration (**p<0.01).