Working hypothesis: UCH L1 up-regulates its expression through β-catenin/TCF signaling.
- Anjali Bheda (260420)
- Wei Yue (230910)
- Anuradha Gullapalli (372131)
- Chris Whitehurst (372132)
- Renshui Liu (372133)
- Joseph S. Pagano (260427)
- Julia Shackelford (260426)
Publication date
February 2013
DOIAbstract
<p>UCH L1 stabilizes β-catenin through deubiquitination and up-regulates β-catenin/TCF transcriptional activity. TCF4/Lef1 transcription factors directly bind to the uch l1 promoter and up-regulate UCH L1 RNA and protein expression.</p
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