Computer visualizations of a mesenteric network and the tumor network color coded for .

<p>Top row: results obtained with measured vessel diameters. Middle and bottom rows: simulated ‘normal adaptation’ and ‘tumor adaptation’. The tumor network with measured diameters and either network subjected to ‘tumor adaptation’ (right column) exhibit high structural heterogeneity and uneven flow distribution in comparison to the mesentery network and either network subjected to ‘normal adaptation’ (left column). For the adapted networks, results of individual randomized runs are shown. Values of oxygen deficit (O_2def) and diameter mismatch (d³_var) were similar to the mean values reported in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000394#pcbi-1000394-g003" target="_blank">Figure 3</a>. For the sake of a better representation of individual vessel segments, only parts of the simulated networks are shown. The mesentery network comprised a total of 546 vessels supplying an area of about 4×7 mm, whereas the tumor vascular network comprised a total of 290 vessels in an area of about 1×0.8 mm.