Influence of p43 overexpression during aging on mitochondrial biogenesis.

<p>(A) electron microscopy experiments from longitudinal sections taken from quadriceps from transgenic mice (p43) and wild-type animals (WT) at 2, 6 and 11 months of age (magnification ×10.000). (B) Relative mtDNA content in quadriceps muscle from transgenic mice (p43) compared to wild-type animals (WT) at 2, 6, 11 and 23 months of age (n = 8 for each group with the exception of 23 month old-group where n = 6). After extraction of muscle DNA, quantitative PCR reactions were performed using ND5 for mtDNA copy estimation, and 18S for the nuclear genome. *p<0.05 and ***p<0.001. Control values at each stage are considered as 100%, and p43 value are expressed in percent of the corresponding control value.