<p>Photomicrographs of hematoxylin and eosin stained lung sections of mice treated with single or double doses of the combination of mAbs after post experimental viral infection with Clade 1 A/Vietnam/1203/2004 H5N1 virus at 6 days post challenge. A) Normal morphology seen in uninfected mice, B) infected and untreated mice, C) mice treated with a single dose of 5 mg/kg of ch-mAbs at 24 h post infection, D) mice treated with two doses of 5 mg/kg of ch-mAbs at 24 h and 72 h post infection.</p
<p>A. Representative hematoxylin and eosin (H & E)-stained sections of lung tissues from control and...
<p><sup>a</sup>Groups of 13 mice were intramuscularly immunized as described in Section 2.6.</p><p><...
<p>Seven days post challenge, mice in each group were euthanized and their lungs were HE-stained for...
<p>HA1-Fc- and HA1-Fdc-vaccinated mice were challenged with 10 LD<sub>50</sub> of three clades (clad...
<p>(A) Viral copy number in the lungs at day 6 post-infection was determined using Q-PCR. The result...
<p>For single dose treatment, 24 h after viral challenge, the mice were treated via intra-peritoneal...
<p>A and E) PBS control group; B and F) homologous VLP-VLP prime-boost group; C and G) homologous DN...
<p>Two weeks after the boost, vaccinated mice were i.n. infected with Ah01/H7N9 (50LD<sub>50</sub>) ...
<p>Histopathology of the lungs of mice on days 2 and 5 after infection with a sublethal dose of infl...
<p>C57BL/6 and BALB/c mice were challenged intranasally with 10<sup>6</sup> TCID<sub>50</sub> of AH1...
<p>Lung samples of M and F virus-infected mice were used for histopathological H&E examination at th...
<p>To assess lung damage and pulmonary inflammation throughout the course of virus infection, we eva...
<p>(A) Survival rate of mice after intranasal inoculation with10<sup>5</sup> TCID<sub>50</sub> of th...
<p>Mice were intragastrically immunized three times at day 0, 14, and 28 with PBS (i and v), the com...
<p><b>(A)</b> Haematoxylin and eosin stained of lung sections from not infected or IAV-infected (50 ...
<p>A. Representative hematoxylin and eosin (H & E)-stained sections of lung tissues from control and...
<p><sup>a</sup>Groups of 13 mice were intramuscularly immunized as described in Section 2.6.</p><p><...
<p>Seven days post challenge, mice in each group were euthanized and their lungs were HE-stained for...
<p>HA1-Fc- and HA1-Fdc-vaccinated mice were challenged with 10 LD<sub>50</sub> of three clades (clad...
<p>(A) Viral copy number in the lungs at day 6 post-infection was determined using Q-PCR. The result...
<p>For single dose treatment, 24 h after viral challenge, the mice were treated via intra-peritoneal...
<p>A and E) PBS control group; B and F) homologous VLP-VLP prime-boost group; C and G) homologous DN...
<p>Two weeks after the boost, vaccinated mice were i.n. infected with Ah01/H7N9 (50LD<sub>50</sub>) ...
<p>Histopathology of the lungs of mice on days 2 and 5 after infection with a sublethal dose of infl...
<p>C57BL/6 and BALB/c mice were challenged intranasally with 10<sup>6</sup> TCID<sub>50</sub> of AH1...
<p>Lung samples of M and F virus-infected mice were used for histopathological H&E examination at th...
<p>To assess lung damage and pulmonary inflammation throughout the course of virus infection, we eva...
<p>(A) Survival rate of mice after intranasal inoculation with10<sup>5</sup> TCID<sub>50</sub> of th...
<p>Mice were intragastrically immunized three times at day 0, 14, and 28 with PBS (i and v), the com...
<p><b>(A)</b> Haematoxylin and eosin stained of lung sections from not infected or IAV-infected (50 ...
<p>A. Representative hematoxylin and eosin (H & E)-stained sections of lung tissues from control and...
<p><sup>a</sup>Groups of 13 mice were intramuscularly immunized as described in Section 2.6.</p><p><...
<p>Seven days post challenge, mice in each group were euthanized and their lungs were HE-stained for...