<p>(A) Treatment of caspase-8 deficient and reconstituted NB7 neuroblastoma cell lines with the thiazole antibiotics revealed that thiopeptide-induced apoptosis mainly involves the intrinsic apoptotic pathway. (B) Leukemia cancer cell lines CEM [IC<sub>50</sub>/µM: Sio-0.73 (0.08); Thio-1.47 (0.1)], HL60 [IC<sub>50</sub>/µM: Sio-0.68 (0.06); Thio-1.78 (0.4)], and U937 [IC<sub>50</sub>/µM: Sio-0.53 (0.1); Thio-0.73 (0.3)], and liver cancer cell lines Hep-3B [IC<sub>50</sub>/µM: Sio-3.6 (1.3); Thio-2.3 (0.8)], Huh7 [IC<sub>50</sub>/µM: Sio-2.3 (0.5); Thio-1.8 (0.2)], and SK-Hep [IC<sub>50</sub>/µM: Sio-3.7 (0.4); Thio-6.0 (1.4)], showed sensitivity in low micromolar range to the thiazole antibiotics as determined by growth inhibition assays. ...
<p>A, B, Analysis of pH2AX and pChk2 expression and PARP cleavage in HCT116, HCT116+3, and HCT116+3+...
Thioalbamide, a thioamidated peptide biosynthesized by Amycolatopsis alba, is a thioviridamide-like ...
The effect of exogenous homocysteine thiolactone (Hcy) on apoptosis initiated by 3-deazaadenosine (c...
Background: Hepatocellular carcinoma (HCC) is one of the most widespread malignancies and is reporte...
Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target i...
Cancer is a global medical problem and, despite research efforts in the field of tumor treatment, th...
Introduction. Sphingosine 1-phosphate (S1P) is involved in many processes such as cell survival, gro...
Introduction. Sphingosine 1-phosphate (S1P) is involved in many processes such as cell survival, gro...
<p>(A) Determination of the mean inhibitory concentration (IC<sub>50</sub>) of thiostrepton in 13 ce...
Background: Hepatocellular carcinoma (HCC) is the fifth most common malignancy in the world and is e...
Background/Aim: Triple-negative breast cancer (TNBC) represents a particular clinical challenge beca...
Purpose: According to some studies, susceptibility of cells to anticancer drug-induced apoptosis is ...
Purpose: The present in vitro study was conducted to evaluate the effects of the histone deacetylase...
Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis p...
The forward chemogenomics strategy allowed us to identify a potent cytotoxic thiazolidine compound a...
<p>A, B, Analysis of pH2AX and pChk2 expression and PARP cleavage in HCT116, HCT116+3, and HCT116+3+...
Thioalbamide, a thioamidated peptide biosynthesized by Amycolatopsis alba, is a thioviridamide-like ...
The effect of exogenous homocysteine thiolactone (Hcy) on apoptosis initiated by 3-deazaadenosine (c...
Background: Hepatocellular carcinoma (HCC) is one of the most widespread malignancies and is reporte...
Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target i...
Cancer is a global medical problem and, despite research efforts in the field of tumor treatment, th...
Introduction. Sphingosine 1-phosphate (S1P) is involved in many processes such as cell survival, gro...
Introduction. Sphingosine 1-phosphate (S1P) is involved in many processes such as cell survival, gro...
<p>(A) Determination of the mean inhibitory concentration (IC<sub>50</sub>) of thiostrepton in 13 ce...
Background: Hepatocellular carcinoma (HCC) is the fifth most common malignancy in the world and is e...
Background/Aim: Triple-negative breast cancer (TNBC) represents a particular clinical challenge beca...
Purpose: According to some studies, susceptibility of cells to anticancer drug-induced apoptosis is ...
Purpose: The present in vitro study was conducted to evaluate the effects of the histone deacetylase...
Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis p...
The forward chemogenomics strategy allowed us to identify a potent cytotoxic thiazolidine compound a...
<p>A, B, Analysis of pH2AX and pChk2 expression and PARP cleavage in HCT116, HCT116+3, and HCT116+3+...
Thioalbamide, a thioamidated peptide biosynthesized by Amycolatopsis alba, is a thioviridamide-like ...
The effect of exogenous homocysteine thiolactone (Hcy) on apoptosis initiated by 3-deazaadenosine (c...