MHC genotyping of macaques against MHC Class Ι alleles.

<p>Macaque samples were tested against a panel of nine MHC class Ι alleles that have previously been shown to be important in SIV epitope presentation or increased resistance to SIV infection <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000433#ppat.1000433-Yant1" target="_blank">[24]</a>,<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000433#ppat.1000433-Kaizu1" target="_blank">[25]</a>,<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000433#ppat.1000433-Loffredo1" target="_blank">[26]</a>. The alleles are: <i>Mamu-A*01</i>, <i>Mamu-A*02</i>, <i>Mamu-A*08</i>, <i>Mamu-A*11, Mamu-B*01</i>, <i>Mamu-B*03</i>, <i>Mamu-B*04, Mamu-B*08, and Mamu-B*17</i>. Animal 90140 is positive for <i>Mamu-A*01</i> and animal 95066 was determined to carry the <i>Mamu-B*01</i> allele. <i>Mamu-A*01</i> has been associated with moderate control of SIVmac239 replication <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000433#ppat.1000433-Zhang1" target="_blank">[29]</a>,<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000433#ppat.1000433-Mothe1" target="_blank">[30]</a>. <i>Mamu-B*01</i> remains on the panel based on early reports of SIV-derived epitopes <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000433#ppat.1000433-Yasutomi1" target="_blank">[31]</a>,<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000433#ppat.1000433-Su1" target="_blank">[32]</a>, but subsequent studies show that <i>Mamu-B*01</i> does not bind SIV-derived epitopes and has no effect on SIV disease progression <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000433#ppat.1000433-Loffredo1" target="_blank">[26]</a>. <b>^{P, N, I, C}</b> denotes protected, non-protected, isotype control, and non-antibody treated control animals, respectively.