Effects of liver-specific conditional deletion of HNF4α on postnatal growth, serum glucose and HNF4α transcript levels.

<p>(A) HBVAlbCre(+)HNF4α^fl/fl pup with the small phenotype, sCre(+), and a control HBVAlbCre(−)HNF4α^fl/fl littermate, Cre(−), at 5.5 days of age. (B) Effect of postnatal age on body weight. (C) Effect of postnatal age on serum glucose levels. (D) Effect of postnatal age on wild-type HNF4α RNA levels in the liver measured by reverse transcription-quantitative polymerase chain reaction. Cre(−), control HBVAlbCre(−)HNF4α^fl/fl mice; Cre(+), HBVAlbCre(+)HNF4α^fl/fl mice with approximately wild-type phenotype; sCre(+), HBVAlbCre(+)HNF4α^fl/fl mice with the small phenotype.