Nscl-2 mutant mice show increased serum adiponectin and resistin levels.

<p>(A) High serum adiponectin levels in adipose Nscl-2 mutant mice. Adiponectin levels in 6–8 months old WT control (n = 4), Nscl-2 (−/−) (n = 9), ob/ob (n = 3), and Nscl-2 (−/−)×ob/ob (n = 1). (B) Increased serum resistin levels in Nscl-2 and Nscl-2/leptin compound mutant mice. Serum resistin level were divided by body weights of WT (n = 23), Nscl-2 (−/−) (n = 15), ob/ob (n = 14) and Nscl-2 (−/−)×ob/ob mice (n = 8). Asterisks indicate significant higher weight matched serum resistin level in Nscl-2 (−/−) (F = 6.3; dF = 3; p<10⁻⁴). (C) Serum resistin levels are inversely proportional to mRNA expression of resistin in WAT (R² = 0.89; p = 0.004). WT (n = 2), Nscl-2 (−/−) (n = 2), ob/ob (n = 2) and Nscl-2 (−/−)×ob/ob (n = 2).