<p>A: Effective vascular permeability was measured 6 days and 15 days after tumor implantation. The vessels in PDGF-C overexpressing tumors have lower permeability both 6 and 15 days following implantation. Normal brain (NB) vessels are relatively impermeable. B: Delivery of the BSA marker (red) is inhibited by PDGF-C overexpression (Green = CD31).</p
PDGF-BB/PDGFR beta signaling plays an important role during vascularization by mediating pericyte re...
Background: The lack of translatable in vitro blood-tumor barrier (BTB) models creates challenges in...
<p>A: Expression of PDGF-C in human samples of gliomas. 27 samples of Grade IV glioma (Tissue Microa...
<p>A: PDGF-C expression causes a decrease in vessel diameter over 15 days of growth. B: At day 15 af...
Background: Recent clinical trials of VEGF inhibitors have shown promise in the treatment of recurre...
Recent clinical trials of VEGF inhibitors have shown promise in the treatment of recurrent glioblast...
The role of platelet-derived growth factor (PDGF) in malignancies involves both autocrine and paracr...
<p>(a) Vardenafil significantly increases the uptake of [<sup>14</sup>C]dextran (MW 70,000 D) by MBE...
Background: Brain tumor vasculature can be significantly compromised and leakier than that of normal...
<p>NG2 expression detected by confocal imaging of U87MG (A) and U87-C (B) tumors using immunohistoch...
The blood-brain barrier (BBB) impedes entry of many drugs into the brain, limiting clinical efficacy...
Purpose—The blood-brain barrier (BBB) is modified to a blood-tumor barrier (BTB) as a brain metastas...
Angiogenesis and anti-angiogenetic medications play an important role in progression and therapy of ...
<p>Mice were pretreated with saline (Group A), 1.6 µg VEGF (Group B), or 3.0 µg VEGF (Group C) by ve...
Recruitment of pericytes is needed to stabilize new vessels formed during angiogenesis or vasculogen...
PDGF-BB/PDGFR beta signaling plays an important role during vascularization by mediating pericyte re...
Background: The lack of translatable in vitro blood-tumor barrier (BTB) models creates challenges in...
<p>A: Expression of PDGF-C in human samples of gliomas. 27 samples of Grade IV glioma (Tissue Microa...
<p>A: PDGF-C expression causes a decrease in vessel diameter over 15 days of growth. B: At day 15 af...
Background: Recent clinical trials of VEGF inhibitors have shown promise in the treatment of recurre...
Recent clinical trials of VEGF inhibitors have shown promise in the treatment of recurrent glioblast...
The role of platelet-derived growth factor (PDGF) in malignancies involves both autocrine and paracr...
<p>(a) Vardenafil significantly increases the uptake of [<sup>14</sup>C]dextran (MW 70,000 D) by MBE...
Background: Brain tumor vasculature can be significantly compromised and leakier than that of normal...
<p>NG2 expression detected by confocal imaging of U87MG (A) and U87-C (B) tumors using immunohistoch...
The blood-brain barrier (BBB) impedes entry of many drugs into the brain, limiting clinical efficacy...
Purpose—The blood-brain barrier (BBB) is modified to a blood-tumor barrier (BTB) as a brain metastas...
Angiogenesis and anti-angiogenetic medications play an important role in progression and therapy of ...
<p>Mice were pretreated with saline (Group A), 1.6 µg VEGF (Group B), or 3.0 µg VEGF (Group C) by ve...
Recruitment of pericytes is needed to stabilize new vessels formed during angiogenesis or vasculogen...
PDGF-BB/PDGFR beta signaling plays an important role during vascularization by mediating pericyte re...
Background: The lack of translatable in vitro blood-tumor barrier (BTB) models creates challenges in...
<p>A: Expression of PDGF-C in human samples of gliomas. 27 samples of Grade IV glioma (Tissue Microa...