KCNE1-D76N and KCNE1-Δ70 shift the voltage dependence of activation of I<sub>Ks</sub>.
- Jerri Chen (373652)
- Renjian Zheng (373656)
- Yonathan F. Melman (373660)
- Thomas V. McDonald (34719)
Publication date
February 2013
DOIAbstract
<p>A) voltage-dependent activation curves, and B) normalized activation curves. Curves were fitted using a Boltzmann function. V<sub>h</sub> for KCNQ1 = −30.3±1.0 mV, KCNQ1/KCNE1 = 9.5±4.2 mV, KCNQ1/KCNE1-D76N = 43.5±3.0 mV, KCNQ1/KCNE1-Δ70 = 71.5±7.0 mV. n = 6, p<0.001 for both mutants compared to wild-type KCNE1.</p
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