T lymphocyte infiltration at the sites of MV-brain infection.

<p>Brain sections from suckling CD150-transgenic (A–E) and nontransgenic littermate mice (F) infected with MV were analyzed by immunohistofluorescence for MV nucleoprotein (N) localization (A–F, in red) and the presence of CD4⁺ (A, in green), CD8⁺ (B, in green) and Foxp3⁺ T cells (C–F, in green). Cell nuclei were counterstained with DAPI (in blue). Infiltrating T CD4⁺ and CD8⁺ lymphocytes were detected in brains from CD150 transgenic mice (A and B, respectively) at the sites of MV infection identified by a N-specific labelling (red dots) but not in their nontransgenic littermates (not shown). Images are shown at 40× original magnification and are representative of three to five mice per group.