Forced lymphopenia does not interfere with bacterial clearance in <i>S. pneumoniae</i> infected hosts.

<p>C57Bl/6 mice were intranasally infected with 1×10⁵ CFU <i>Streptococcus pneumoniae</i> TIGR4 and at the same time intraperitoneally injected with PBS (•) or R-848 (○). Mice were sacrificed 4 and 24 hours later and <i>S. pneumoniae</i> CFU counts in nasopharyngeal lavage (A), bronchoalveolar lavage (B) and lung homogenates (C) were assessed. Data show values of individual mice together with group means (horizontal lines) and are compiled from two independent experiments.