Cortical Aβ deposition in brains of humans and mice.

<p>Representative examples of immunostaining for Aβ in brain sections obtained from 6-month-old (b) and 24-month-old NEP-deficient mice (d) and corresponding age-matched wildtype controls (a,c), and from post mortem human brain material of a 75-year-old Alzheimer patient (f) and a 31-year-old human control (e). Images shown in a–d represent the mouse somatosensory cortex (barrel field), while human brain sections (e,f) were obtained from the temporal cortex. All sections were immunostained under the same conditions and in the same experimental session with the biotinylated primary antiserum 4G8 which is known to react with both human and murine Aβ peptides. Scale bar represents 200 µm.