Loss of TAK1 disrupts homeostatic proliferation of the intestinal epithelium.

<p>A Distal colon was isolated from TNFR1KO and TNFR1KO/TAK1^IEKO mice treated with water or 2.5% DSS for 3 days. Mice were injected with 0.1 mg/g of 5-bromo-2′-deoxyuridine (BrdU) 2 h prior to sacrifice. Immunostaining for BrdU was performed and BrdU-positive cells were counted. Each bar represents a mean value±SE (N = 5 per group, ** = p<0.01). B Representative BrdU staining and H&E staining at 3 days DSS treatment. Original magnifications; ×200 (BrdU staining) and ×40 (H&E staining).